Patients should be advised to measure TUZISTRA XR with an accurate milliliter measuring device. Patients should be informed that a household teaspoon is not an accurate measuring device and could lead to overdosage, which can result in serious adverse reactions.¹

Simplified dosing makes treatment more convenient

12-HOUR DOSING OF TUZISTRA XR IS DESIGNED TO ALIGN WITH YOUR PATIENTS’ SCHEDULES, DAY AND NIGHT¹

Which dosing schedule best supports your patients’ needs?

4 to 6 doses
over 24 hours^3‡

^‡Up to 120 mg of codeine.

Just 2 doses
over 24 hours^1§

^§80 mg of codeine.

Prescribe All-Day, All-Night TUZISTRA XR

JUST 1 DOSE EVERY 12 HOURS¹

Dosed at 10 mL every 12 hours not to exceed 2 doses in 24 hours¹
TUZISTRA XR is a CIII cough medication¹
29.5 mg of codeine (equivalent to 40 mg codeine phosphate) and 5.6 mg of chlorpheniramine (equivalent to 8 mg chlorpheniramine maleate) per 10-mL dose¹

No Generic Equivalent Available²

Pharmacists: Order TUZISTRA XR Today

STOCK NOW SO PATIENTS DON’T HAVE TO WAIT 24 TO 48 HOURS FOR THEIR PRESCRIPTION

Ordering Information

Description	TUZISTRA XR (codeine polistirex and chlorpheniramine polistirex) contains 29.5 mg of codeine (equivalent to 40 mg codeine phosphate) and 5.6 mg of chlorpheniramine (equivalent to 8 mg chlorpheniramine maleate) per 10-mL dose¹
NDC number	69654-480-01
Packaging	16 fl oz (473 mL) bottle

View TUZISTRA XR pharmacy codes

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IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

Children less than 12 years of age

Postoperative management in children younger than 18 years of age following tonsillectomy and/or adenoidectomy.

Patients with known hypersensitivity to codeine, chlorpheniramine, or any of the product components of TUZISTRA XR.

WARNINGS AND PRECAUTIONS

Risk of death in ultra-rapid metabolizers: Conversion of codeine into its active metabolite, morphine, may occur more rapidly and completely resulting in higher than expected morphine levels and respiratory depression or death.

Risks from concomitant use with benzodiazepines or other CNS depressants: Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.

Dose-related respiratory depression: Use with caution.

Drug dependence: Prescribe with caution that is appropriate to the use of other opioids.

Head injury and increased intracranial pressure: Avoid in patients with head injury, intra-cranial lesions, or increased intracranial pressure.

Activities requiring mental alertness: Avoid engaging in hazardous tasks requiring complete mental alertness such as driving or operating heavy machinery. Avoid concurrent use of alcohol or other central nervous system depressants.

Acute abdominal conditions: Use with caution in patients with acute abdominal conditions.

Special risk patients: Caution in elderly patients and those with asthma, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture.

ADVERSE REACTIONS:

Common adverse reactions of TUZISTRA XR include: nausea and vomiting, constipation, abdominal distension, abdominal pain, blurred vision, diplopia, visual disturbances, confusion, dizziness, depression, drowsiness, sedation, headache, euphoria, facial dyskinesia, feeling faint, light-headedness, general feeling of discomfort or illness, excitability, nervousness, agitation, restlessness, somnolence, insomnia, dyskinesia, irritability, tremor.

To report SUSPECTED ADVERSE REACTIONS, contact Tris Pharma, at 1-732-940-0358 (U.S. only) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Amerisource	10192387
Anda	202175
Cardinal	5493556
H.D. Smith	57748223
McKesson	3546645
Morris and Dickson	494039
Mutual	327866
Smith	870360
TUZISTRA XR IS A CIII COUGH MEDICATION¹

One dose
Two times a day

Calm their coughs. All day. All night. Prescribe 12-hr TUZISTRA XR.¹

Simplified dosing makes treatment more convenient

12-HOUR DOSING OF TUZISTRA XR IS DESIGNED TO ALIGN WITH YOUR PATIENTS’ SCHEDULES, DAY AND NIGHT¹

Prescribe All-Day, All-Night TUZISTRA XR

JUST 1 DOSE EVERY 12 HOURS¹

Pharmacists: Order TUZISTRA XR Today

STOCK NOW SO PATIENTS DON’T HAVE TO WAIT 24 TO 48 HOURS FOR THEIR PRESCRIPTION

Ordering Information

TUZISTRA^® XR (codeine polistirex and chlorpheniramine polistirex) extended-release oral suspension, CIII

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS:

One dose Two times a day

Calm their coughs. All day. All night. Prescribe 12-hr TUZISTRA XR.1

Simplified dosing makes treatment more convenient

12-HOUR DOSING OF TUZISTRA XR IS DESIGNED TO ALIGN WITH YOUR PATIENTS’ SCHEDULES, DAY AND NIGHT1

Prescribe All-Day, All-Night TUZISTRA XR

JUST 1 DOSE EVERY 12 HOURS1

Pharmacists: Order TUZISTRA XR Today

STOCK NOW SO PATIENTS DON’T HAVE TO WAIT 24 TO 48 HOURS FOR THEIR PRESCRIPTION

Ordering Information

TUZISTRA® XR (codeine polistirex and chlorpheniramine polistirex) extended-release oral suspension, CIII

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS:

One dose
Two times a day

Calm their coughs. All day. All night. Prescribe 12-hr TUZISTRA XR.¹

12-HOUR DOSING OF TUZISTRA XR IS DESIGNED TO ALIGN WITH YOUR PATIENTS’ SCHEDULES, DAY AND NIGHT¹

JUST 1 DOSE EVERY 12 HOURS¹

TUZISTRA^® XR (codeine polistirex and chlorpheniramine polistirex) extended-release oral suspension, CIII